Fly midgut regeneration induced by Pseudomonas entomophila Pe infection. The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage. Author manuscript; available in PMC Sep Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila. How the InR and PVR signals interface with the other pathways described above remains to be investigated.
Oscillations in notch signaling regulate maintenance of neural progenitors.
Intestinal stem cells in the adult Drosophila midgut.
The recent discovery of somatic stem cells in adult Drosophilaparticularly the intestinal stem cells ISCs of the midgut, has established Drosophila as an exciting model to study stem cell-mediated adult tissue homeostasis and regeneration. EGFR signaling is required for compensatory ISC proliferation and midgut regeneration in gut injury models [ 373840 ] and is also required for ISC division and midgut homeostasis under normal culture conditions [ 37 — 40 ]. Evidence that stem cells reside in the adult Drosophila midgut epithelium. E spl -C gene products then inhibit the expression of another bHLH transcription factor, daughterless Dawhich in turn inactivates genes that are required for maintaining stem cell fate. Notch signals control the fate of immature progenitor cells in the intestine. In Drosophilain contrast, Notch activation in ISCs inhibits their proliferation and promotes their differentiation into mature polyploid ECs, leading rapidly to stem cell depletion [ 910 ].